Publications.                                 Google - scholar link

40.  Jansen C, Shimoda LMN, Kawakami JK, Ang L, Bacani AJ, Baker JD, Badowski C, Speck M, Stokes AJ, Small-Howard AL, Turner H. Myrcene and terpene regulation of TRPV1. Channels (Austin). 2019 Dec;13(1):344-366. doi: 10.1080/19336950.2019.1654347. PubMed PMID: 31446830.            

39.  Horton JS, Shiraishi T, Alfulaij N, Small-Howard AL, Turner HC, Kurokawa T, Mori Y, Stokes AJ. TRPV1 is a component of the atrial natriuretic signaling complex, and using orally delivered antagonists, presents a valid therapeutic target in the longitudinal reversal and treatment of cardiac hypertrophy and heart failure. Channels (Austin). 2019 Dec;13(1):1-16. doi: 10.1080/19336950.2018.1547611. PubMed PMID: 30424709; PubMed Central PMCID: PMC6298697.

38.  Aldan JT, Jansen C, Speck M, Maaetoft-Udsen K, Cordasco EA, Faiai M, Shimoda LMN, Greineisen WE, Turner H, Stokes AJ. Insulin-induced lipid body accumulation  is accompanied by lipid remodelling in model mast cells. Adipocyte. 2019 Dec;8(1):265-279. doi: 10.1080/21623945.2019.1636624. PubMed PMID: 31311389.

37.  Jansen C, Shimoda LMN, Starkus J, Lange I, Rysavy N, Maaetoft-Udsen K, Tobita C, Stokes AJ, Turner H. In vitro exposure to Hymenoptera venom and constituents activates discrete ionotropic pathways in mast cells. Channels (Austin). 2019Dec;13(1):264-286. doi: 10.1080/19336950.2019.1629225. PubMed PMID: 31237176.

36.  Starkus J, Jansen C, Shimoda LMN, Stokes AJ, Small-Howard AL, Turner H. Diverse TRPV1 responses to cannabinoids. Channels (Austin). 2019 May 17;. doi: 10.1080/19336950.2019.1619436. PubMed PMID: 31096838.

35.  Jansen C, Tobita C, Umemoto EU, Starkus J, Rysavy NM, Shimoda LMN, Sung C, Stokes AJ, Turner H. Calcium-dependent, non-apoptotic, large plasma membrane bleb formation in physiologically stimulated mast cells and basophils. J Extracellular Vesicles. 2019;8(1):1578589. doi: 10.1080/20013078.2019.1578589. eCollection 2019. PubMed PMID: 30815238; PubMed Central PMCID: PMC6383620.

34.  Reimann-Philipp U, Speck M, Orser C, Johnson S, Hilyard A, Turner H, Stokes A, Small-Howard A. Cannabis Chemovar Nomenclature Misrepresents Chemical and Genetic Diversity; Survey of Variations in Chemical Profiles and Genetic Markers in Nevada Medical Cannabis Samples. Cannabis and Cannabinoid Research. 2019; doi: 10.1089/can.2018.0063.

33.  Alfulaij N, Meiners F, Michalek J, Small-Howard AL, Turner HC, Stokes AJ. Cannabinoids, the Heart of the Matter. J Am Heart Assoc. 2018 Jul 13;7(14). doi: 10.1161/JAHA.118.009099. Review. PubMed PMID: 30006489; PubMed Central PMCID: PMC6064852.

32 Turner H, Chueh D, Ortiz T, Stokes A, Small-Howard A. Cannabinoid Therapeutics in Parkinson’s Disease: Promise and Paradox. Journal of Herbs, Spices & Medicinal Plants. 2017/07; 23(3):231-248. doi: 10.1080/10496475.2017.1312724.

31. Jansen C, Speck M, Greineisen WE, Maaetoft-Udsen K, Cordasco E, Shimoda LM, Stokes AJ, Turner H. Transcriptional and Functional Plasticity Induced by Chronic Insulin Exposure in a Mast Cell-Like Basophilic Leukemia Cell Model. J Immunobiol. 2017;2(4). pii: 135. doi: 10.4172/2476-1966.1000135. Epub 2017 Dec 11. PubMed PMID: 29430572; PubMed Central PMCID: PMC5804893.

30. Kumar M, Ching L, Astern J, Lim E, Stokes AJ, Melish M, Nerurkar VR. Prevalence of Antibodies to Zika Virus in Mothers from Hawaii Who Delivered Babies with and without Microcephaly between 2009-2012. PLoS Negl Trop Dis. 2016 Dec 20;10(12):e0005262. doi: 10.1371/journal.pntd.0005262. eCollection 2016 Dec. PubMed PMID: 27997547; PubMed Central PMCID: PMC5215948.

29.Flores D, Miller AL, Showman A, Tobita C, Shimoda LM, Sung C, Stokes AJ, Tomberlin JK, Carter DO, Turner H. Fluorescence Imaging of Posterior Spiracles from Second and Third Instars of Forensically Important Chrysomya rufifacies (Diptera: Calliphoridae). J Forensic Sci. 2016 Nov;61(6):1578-1587. doi: 10.1111/1556-4029.13189. Epub 2016 Oct 5. PubMed PMID: 27706817; PubMed Central PMCID: PMC5118101.

28. Agrawal S., Aranda M., Baumgarten S., Belcaid M., Drake J., Erwin D., Foret S., Gates R.D., Gruber D.F., Hanna B., Lesser M.P., Levy O., Liew Y.J., MacManes M., Mass T., Medina M., Mehr S., Meyer E., Price D.C., Putnam H., Qiu H., Shinzato C., Shoguchi E., Stokes A.J., Tambutté S., Tchernov D., Voolstra C., Wagner N., Weber A.P.M., Weiss V., Zelzion E., Zoccola D., Falkowski P., and Bhattacharya D.. What is a coral? Comparative genomics reveals the genetic machinery underlying the evolution of corals. Accepted • eLife, April 2016.

 

27.    Shimoda, L. M. et al. Differential regulation of calcium signalling pathways by components of Piper methysticum ('Awa). Phytotherapy research : PTR 29, 582-590, doi:10.1002/ptr.5291 (2015).


26    Horton, J. S., Wakano, C. T., Speck, M. & Stokes, A. J. Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis. Channels (Austin, Tex.) 9, 21-29, doi:10.4161/19336950.2014.978676 (2015).


25    Berry, M. J. et al. Medical school hotline: the research mission of the cell and molecular biology department and program at the john a. Burns school of medicine. Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health 74, 150-153 (2015).


24    Umemoto, E. Y. et al. Single-walled carbon nanotube exposure induces membrane rearrangement and suppression of receptor-mediated signalling pathways in model mast cells. Toxicology letters 229, 198-209, doi:10.1016/j.toxlet.2014.06.009 (2014).


23    Rysavy, N. M. et al. Beyond apoptosis: the mechanism and function of phosphatidylserine asymmetry in the membrane of activating mast cells. Bioarchitecture 4, 127-137, doi:10.1080/19490992.2014.995516 (2014).


22    Horton, J. S. & Stokes, A. J. The transmembrane channel-like protein family and human papillomaviruses: Insights into epidermodysplasia verruciformis and progression to squamous cell carcinoma. Oncoimmunology 3, e28288, doi:10.4161/onci.28288 (2014).


21    Horton, J. S., Buckley, C. L., Alvarez, E. M., Schorlemmer, A. & Stokes, A. J. The calcium release-activated calcium channel Orai1 represents a crucial component in hypertrophic compensation and the development of dilated cardiomyopathy. Channels (Austin, Tex.) 8, 35-48, doi:10.4161/chan.26581 (2014).


20    Greineisen, W. E. et al. Lipid body accumulation alters calcium signaling dynamics in immune cells. Cell calcium 56, 169-180, doi:10.1016/j.ceca.2014.06.004 (2014).


19    Berry, M. J. et al. Medical school hotline: The educational mission of the cell and molecular biology department and program at the John A. Burns School of Medicine. Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health 73, 362-364 (2014).


18    Horton, J. S., Buckley, C. L. & Stokes, A. J. Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice. Channels (Austin, Tex.) 7, 17-22, doi:10.4161/chan.23006 (2013).


17  Shimoda, L. M., Park, C., Stokes, A. J., Gomes, H. H. & Turner, H. Pacific island 'Awa (Kava) extracts, but not isolated kavalactones, promote proinflammatory responses in model mast cells. Phytotherapy research : PTR 26, 1934-1941, doi:10.1002/ptr.4652 (2012).


16    Buckley, C. L. & Stokes, A. J. Mice lacking functional TRPV1 are protected from pressure overload cardiac hypertrophy. Channels (Austin, Tex.) 5, 367-374, doi:10.4161/chan.5.4.17083 (2011).


15    Buckley, C. L. & Stokes, A. J. Corin-deficient W-sh mice poorly tolerate increased cardiac afterload. Regulatory peptides 172, 44-50, doi:10.1016/j.regpep.2011.08.006 (2011).


14    Prasad, P., Yanagihara, A. A., Small-Howard, A. L., Turner, H. & Stokes, A. J. Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A. Journal of immunology (Baltimore, Md. : 1950) 181, 5024-5034 (2008).


13    Turner, H., del Carmen, K. A. & Stokes, A. Link between TRPV channels and mast cell function. Handbook of experimental pharmacology, 457-471, doi:10.1007/978-3-540-34891-7_27 (2007).


12    Cheng, H. et al. TRPM4 controls insulin secretion in pancreatic beta-cells. Cell calcium 41, 51-61, doi:10.1016/j.ceca.2006.04.032 (2007).


11    Stokes, A. J. et al. Fcepsilon RI control of Ras via inositol (1,4,5) trisphosphate 3-kinase and inositol tetrakisphosphate. Cellular signalling 18, 640-651, doi:10.1016/j.cellsig.2005.06.003 (2006).


10    Stokes, A. et al. TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. Cellular signalling 18, 1584-1594, doi:10.1016/j.cellsig.2005.12.009 (2006).


9    Stokes, A. J., Wakano, C., Del Carmen, K. A., Koblan-Huberson, M. & Turner, H. Formation of a physiological complex between TRPV2 and RGA protein promotes cell surface expression of TRPV2. Journal of cellular biochemistry 94, 669-683, doi:10.1002/jcb.20331 (2005).


8    Stokes, A. J., Shimoda, L. M., Koblan-Huberson, M., Adra, C. N. & Turner, H. A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells. The Journal of experimental medicine 200, 137-147, doi:10.1084/jem.20032082 (2004).


7    Barnhill, J. C. et al. RGA protein associates with a TRPV ion channel during biosynthesis and trafficking. Journal of cellular biochemistry 91, 808-820, doi:10.1002/jcb.10775 (2004).


6    Turner, H., Fleig, A., Stokes, A., Kinet, J. P. & Penner, R. Discrimination of intracellular calcium store subcompartments using TRPV1 (transient receptor potential channel, vanilloid subfamily member 1) release channel activity. The Biochemical journal 371, 341-350, doi:10.1042/bj20021381 (2003).


5    Samson, M. T. et al. Differential roles of CB1 and CB2 cannabinoid receptors in mast cells. Journal of immunology (Baltimore, Md. : 1950) 170, 4953-4962 (2003).


4    Guerrero, A. P. et al. Demographic and clinical characteristics of adolescents in Hawaii with obsessive-compulsive disorder. Archives of pediatrics & adolescent medicine 157, 665-670, doi:10.1001/archpedi.157.7.665 (2003).


3    Perraud, A. L. et al. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 411, 595-599, doi:10.1038/35079100 (2001).


2    Nadler, M. J. et al. LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature 411, 590-595, doi:10.1038/35079092 (2001).


1    Haworth, K., Shu, K. K., Stokes, A., Morris, R. & Stoker, A. The expression of receptor tyrosine phosphatases is responsive to sciatic nerve crush. Molecular and cellular neurosciences 12, 93-104, doi:10.1006/mcne.1998.0707 (1998).

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re: https://www.sciencenews.org/article/map-zika-virus-reveals-how-it-shifts-it-matures

re: https://www.sciencenews.org/article/map-zika-virus-reveals-how-it-shifts-it-matures

[28] Coral contains a plethora of ion channels. Many used for environmental sensing.

 
[26] Over expression of TPCN1 causes multi nucleation.

[26] Over expression of TPCN1 causes multi nucleation.

[22] Reverse homology modeling of TMC8

[22] Reverse homology modeling of TMC8

[21] Knock out Orai1 causes rapid left ventricular dilation and early death, in mice modeled for heart failure (TAC).

[21] Knock out Orai1 causes rapid left ventricular dilation and early death, in mice modeled for heart failure (TAC).

[18] Treating mice with a TRPV1 inhibitor (BCTC) protects the heart from heart failure. In untreated mice, the ventricle dilates (Vehicle).

[18] Treating mice with a TRPV1 inhibitor (BCTC) protects the heart from heart failure. In untreated mice, the ventricle dilates (Vehicle).

[14] SCG3 over expression causes vesicle formation in mast cells.

[14] SCG3 over expression causes vesicle formation in mast cells.

[8] TRPV2 in mast cells.

[8] TRPV2 in mast cells.

[8] TRPV2 in mast cells. Calcium flux with temperature.

[8] TRPV2 in mast cells. Calcium flux with temperature.

[2] TRPM2 expression, and ADPR gating

[2] TRPM2 expression, and ADPR gating

[2] TRPM7 regulation by Mg•ATP.

[2] TRPM7 regulation by Mg•ATP.